Pseudomonas aeruginosa PAO1, PA4378 (warB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4378
Name
warB
Synonym: inaA
Replicon chromosome
Genomic location 4909401 - 4910105 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
Comment

Cross-References

RefSeq NP_253068.1
GI 15599574
Affymetrix PA4378_inaA_at
Entrez 881313
GenBank AAG07766.1
INSDC AAG07766.1
NCBI Locus Tag PA4378
protein_id(GenBank) gb|AAG07766.1|AE004854_2|gnl|PseudoCAP|PA4378
TIGR NTL03PA04379
UniParc UPI00000C5CEE
UniProtKB Acc Q9HW24
UniProtKB ID Q9HW24_PSEAE
UniRef100 UniRef100_W0YWA7
UniRef50 UniRef50_G8Q6V5
UniRef90 UniRef90_A6VB50

Product

Feature Type CDS
Coding Frame 1
Product Name
WarB
Product Name Confidence: Class 2
Synonyms InaA protein
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 9.34
Kyte-Doolittle Hydrophobicity Value -0.577
Molecular Weight (kDa) 26.7
Isoelectric Point (pI) 9.85

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 15 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003968 (519 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4378
Search term: warB
Search term: WarB

Human Homologs

References

pH dependence and gene structure of inaA in Escherichia coli.
White S, Tuttle FE, Blankenhorn D, Dosch DC, Slonczewski JL
J Bacteriol 1992 Mar;174(5):1537-43
PubMed ID: 1537798
Dual regulation of inaA by the multiple antibiotic resistance (mar) and superoxide (soxRS) stress response systems of Escherichia coli.
Rosner JL, Slonczewski JL
J Bacteriol 1994 Oct;176(20):6262-9
PubMed ID: 7928997
Cyclic-di-GMP regulates lipopolysaccharide modification and contributes to Pseudomonas aeruginosa immune evasion.
McCarthy RR, Mazon-Moya MJ, Moscoso JA, Hao Y, Lam JS, Bordi C, Mostowy S, Filloux A
Nat Microbiol 2017 Mar 6;2:17027
PubMed ID: 28263305