Pseudomonas aeruginosa PAO1, PA4379 (warA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4379
Name
warA
Replicon chromosome
Genomic location 4910108 - 4910791 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
Comment

Cross-References

RefSeq NP_253069.1
GI 15599575
Affymetrix PA4379_at
DNASU PaCD00007894
Entrez 881358
GenBank AAG07767.1
INSDC AAG07767.1
NCBI Locus Tag PA4379
protein_id(GenBank) gb|AAG07767.1|AE004854_3|gnl|PseudoCAP|PA4379
TIGR NTL03PA04380
UniParc UPI00000C5CEF
UniProtKB Acc Q9HW23
UniProtKB ID Q9HW23_PSEAE
UniRef100 UniRef100_Q9HW23
UniRef50 UniRef50_A0A0B7DGW2
UniRef90 UniRef90_Q9HW23

Product

Feature Type CDS
Coding Frame 1
Product Name
WarA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 8.31
Kyte-Doolittle Hydrophobicity Value -0.433
Molecular Weight (kDa) 26.2
Isoelectric Point (pI) 9.70

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 33 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003969 (526 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4379
Search term: warA
Search term: WarA

Human Homologs

References

Cyclic-di-GMP regulates lipopolysaccharide modification and contributes to Pseudomonas aeruginosa immune evasion.
McCarthy RR, Mazon-Moya MJ, Moscoso JA, Hao Y, Lam JS, Bordi C, Mostowy S, Filloux A
Nat Microbiol 2017 Mar 6;2:17027
PubMed ID: 28263305