Pseudomonas aeruginosa PAO1, PA4456

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4456
Name
Synonym: yrbF
Replicon chromosome
Genomic location 4988082 - 4988891 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253146.1
GI 15599652
Affymetrix PA4456_at
DNASU PaCD00007932
Entrez 881000
GenBank AAG07844.1
INSDC AAG07844.1
NCBI Locus Tag PA4456
protein_id(GenBank) gb|AAG07844.1|AE004859_13|gnl|PseudoCAP|PA4456
TIGR NTL03PA04457
UniParc UPI00000C5D1B
UniProtKB Acc Q9HVW1
UniProtKB ID Q9HVW1_PSEAE
UniRef100 UniRef100_W0YZJ0
UniRef50 UniRef50_A0A085G1V4
UniRef90 UniRef90_V6AL59

Product

Feature Type CDS
Coding Frame 1
Product Name
probable ATP-binding component of ABC transporter
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.07
Kyte-Doolittle Hydrophobicity Value 0.018
Molecular Weight (kDa) 29.6
Isoelectric Point (pI) 6.96

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7CHA MEMBRANE PROTEIN 07/05/20 Cryo-EM structure of P.aeruginosa MlaFEBD with AMPPNP Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1); Pseudomonas aeruginosa PAO1 3.9 ELECTRON MICROSCOPY 100.0
7CH8 MEMBRANE PROTEIN 07/05/20 Cryo-EM structure of P.aeruginosa MlaFEBD with ADP-V Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 3.9 ELECTRON MICROSCOPY 100.0
7CH9 MEMBRANE PROTEIN 07/05/20 Cryo-EM structure of P.aeruginosa MlaFEBD Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 3.5 ELECTRON MICROSCOPY 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004045 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4456

Human Homologs

Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 4 [Source:HGNC Symbol;Acc:HGNC:45]
E-value: 8.7e-19
Percent Identity: 30.4
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 4 [Source:HGNC Symbol;Acc:HGNC:45]
E-value: 8.7e-19
Percent Identity: 30.4
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 4 [Source:HGNC Symbol;Acc:HGNC:45]
E-value: 8.7e-19
Percent Identity: 30.4

References

No references are associated with this feature.