Pseudomonas aeruginosa PAO1, PA4468 (sodM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4468
Name
sodM
Synonym: sodA
Replicon chromosome
Genomic location 4997439 - 4998050 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253158.1
GI 15599664
Affymetrix PA4468_sodM_at
Entrez 881040
GenBank AAG07856.1
INSDC AAG07856.1
NCBI Locus Tag PA4468
protein_id(GenBank) gb|AAG07856.1|AE004860_12|gnl|PseudoCAP|PA4468
TIGR NTL03PA04469
UniParc UPI0000135C3F
UniProtKB Acc P53652
UniProtKB ID SODM_PSEAE
UniRef100 UniRef100_P53652
UniRef50 UniRef50_P00449
UniRef90 UniRef90_P53652

Product

Feature Type CDS
Coding Frame 1
Product Name
superoxide dismutase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Verified using two-dimensional gel electrophoresis, MALDI-TOF MS and peptide mass mapping(pI:5.8, molecular weight:22.5, PMID:21674802)
Charge (pH 7) -3.85
Kyte-Doolittle Hydrophobicity Value -0.402
Molecular Weight (kDa) 22.5
Isoelectric Point (pI) 6.23

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 529 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004057 (488 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4468
Search term: sodM

Human Homologs

Ensembl 110, assembly GRCh38.p14
superoxide dismutase 2 [Source:HGNC Symbol;Acc:HGNC:11180]
E-value: 8.8e-48
Percent Identity: 48.7
Ensembl 110, assembly GRCh38.p14
superoxide dismutase 2 [Source:HGNC Symbol;Acc:HGNC:11180]
E-value: 8.8e-48
Percent Identity: 48.7

References

Cloning and characterization of the Pseudomonas aeruginosa sodA and sodB genes encoding manganese- and iron-cofactored superoxide dismutase: demonstration of increased manganese superoxide dismutase activity in alginate-producing bacteria.
Hassett DJ, Woodruff WA, Wozniak DJ, Vasil ML, Cohen MS, Ohman DE
J Bacteriol 1993 Dec;175(23):7658-65
PubMed ID: 8244935
Proteomics of the oxidative stress response induced by hydrogen peroxide and paraquat reveals a novel AhpC-like protein in Pseudomonas aeruginosa.
Hare NJ, Scott NE, Shin EH, Connolly AM, Larsen MR, Palmisano G, Cordwell SJ
Proteomics 2011 Aug;11(15):3056-69
PubMed ID: 21674802