Pseudomonas aeruginosa PAO1, PA4558

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4558
Name
Synonym: yaaD
Synonym: fkbX
Replicon chromosome
Genomic location 5106016 - 5106456 (- strand)

Cross-References

RefSeq NP_253248.1
GI 15599754
Affymetrix PA4558_at
DNASU PaCD00007973
Entrez 877619
GenBank AAG07946.1
INSDC AAG07946.1
NCBI Locus Tag PA4558
protein_id(GenBank) gb|AAG07946.1|AE004869_10|gnl|PseudoCAP|PA4558
TIGR NTL03PA04559
UniParc UPI00000C5D61
UniProtKB Acc Q9HVM6
UniProtKB ID Q9HVM6_PSEAE
UniRef100 UniRef100_W0YZ90
UniRef50 UniRef50_P21863
UniRef90 UniRef90_A6VBU5

Product

Feature Type CDS
Coding Frame 1
Product Name
probable peptidyl-prolyl cis-trans isomerase, FkbP-type
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by iTRAQ (PMID:21863142).
Charge (pH 7) -9.52
Kyte-Doolittle Hydrophobicity Value -0.214
Molecular Weight (kDa) 16.0
Isoelectric Point (pI) 4.26

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 399 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004217 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4558

Human Homologs

References

Nucleotide sequence of the Pseudomonas fluorescens signal peptidase II gene (lsp) and flanking genes.
Isaki L, Beers R, Wu HC
J Bacteriol 1990 Nov;172(11):6512-7
PubMed ID: 2121716
The Escherichia coli SlyD is a metal ion-regulated peptidyl-prolyl cis/trans-isomerase.
Hottenrott S, Schumann T, Plückthun A, Fischer G, Rahfeld JU
J Biol Chem 1997 Jun 20;272(25):15697-701
PubMed ID: 9188461
Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient.
Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB
Front Microbiol 2011;2:162
PubMed ID: 21863142