Pseudomonas aeruginosa PAO1, PA4560 (ileS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA4560
Name
ileS
Replicon chromosome
Genomic location 5106951 - 5109782 (- strand)

Cross-References

RefSeq NP_253250.1
GI 15599756
Affymetrix PA4560_ileS_at
Entrez 878194
GenBank AAG07948.1
INSDC AAG07948.1
NCBI Locus Tag PA4560
protein_id(GenBank) gb|AAG07948.1|AE004869_12|gnl|PseudoCAP|PA4560
TIGR NTL03PA04561
UniParc UPI00000C5D62
UniProtKB Acc Q9HVM4
UniProtKB ID SYI_PSEAE
UniRef100 UniRef100_Q9HVM4
UniRef50 UniRef50_Q9HVM4
UniRef90 UniRef90_Q9HVM4

Product

Feature Type CDS
Coding Frame 1
Product Name
isoleucyl-tRNA synthetase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -16.70
Kyte-Doolittle Hydrophobicity Value -0.265
Molecular Weight (kDa) 105.5
Isoelectric Point (pI) 6.09

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 668 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004219 (554 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4560
Search term: ileS

Human Homologs

Ensembl 97, assembly GRCh38.p12
isoleucyl-tRNA synthetase 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:29685]
E-value: 9.9e-159
Percent Identity: 35.7

References

Synthesis of the isoleucyl- and valyl-tRNA synthetases and the isoleucine-valine biosynthetic enzymes in a threonine deaminase regulatory mutant of Escherichia coli K-12.
Singer PA, Levinthal M, Williams LS
J Mol Biol 1984 May 5;175(1):39-55
PubMed ID: 6374157
Nucleotide sequence of the Escherichia coli prolipoprotein signal peptidase (lsp) gene.
Innis MA, Tokunaga M, Williams ME, Loranger JM, Chang SY, Chang S, Wu HC
Proc Natl Acad Sci U S A 1984 Jun;81(12):3708-12
PubMed ID: 6374664