Pseudomonas aeruginosa PAO1, PA4585 (rtcA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4585
Name
rtcA
Synonym: yhgK
Replicon chromosome
Genomic location 5134689 - 5135714 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_253275.1
GI 15599781
Affymetrix PA4585_rtcA_at
DNASU PaCD00007987
Entrez 881010
GenBank AAG07973.1
INSDC AAG07973.1
NCBI Locus Tag PA4585
protein_id(GenBank) gb|AAG07973.1|AE004872_4|gnl|PseudoCAP|PA4585
TIGR NTL03PA04586
UniParc UPI00001352C9
UniProtKB Acc Q9HVJ9
UniProtKB ID RTCA_PSEAE
UniRef100 UniRef100_Q02G92
UniRef50 UniRef50_P58127
UniRef90 UniRef90_Q02G92

Product

Feature Type CDS
Coding Frame 1
Product Name
RNA 3'-terminal phosphate cyclase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 2.99
Kyte-Doolittle Hydrophobicity Value -0.088
Molecular Weight (kDa) 36.6
Isoelectric Point (pI) 7.89

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 110 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004243 (331 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4585
Search term: rtcA

Human Homologs

References

The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea.
Genschik P, Billy E, Swianiewicz M, Filipowicz W
EMBO J 1997 May 15;16(10):2955-67
PubMed ID: 9184239
Characterization of the Escherichia coli RNA 3'-terminal phosphate cyclase and its sigma54-regulated operon.
Genschik P, Drabikowski K, Filipowicz W
J Biol Chem 1998 Sep 25;273(39):25516-26
PubMed ID: 9738023