Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA4598
|
Name |
mexD
|
Replicon | chromosome |
Genomic location | 5151078 - 5154209 (- strand) |
Transposon Mutants | 4 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 8 transposon mutants in orthologs |
RefSeq | NP_253288.1 |
GI | 15599794 |
Affymetrix | PA4598_mexD_at |
Entrez | 881071 |
GenBank | AAG07986.1 |
INSDC | AAG07986.1 |
NCBI Locus Tag | PA4598 |
protein_id(GenBank) | gb|AAG07986.1|AE004873_8|gnl|PseudoCAP|PA4598 |
TIGR | NTL03PA04599 |
UniParc | UPI00000C5D80 |
UniProtKB Acc | Q9HVI9 |
UniProtKB ID | Q9HVI9_PSEAE |
UniRef100 | UniRef100_Q9HVI9 |
UniRef50 | UniRef50_P31224 |
UniRef90 | UniRef90_Q9HVI9 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexD
|
Synonyms |
RND multidrug efflux transporter MexD |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -16.84 |
Kyte-Doolittle Hydrophobicity Value | 0.401 |
Molecular Weight (kDa) | 111.6 |
Isoelectric Point (pI) | 4.83 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
MexD | MexD is the multidrug inner membrane transporter of the MexCD-OprJ complex. [PMID:9449262, PMID:8878035] | ARO:3000801 | protein homolog model | Strict | 1845.1 | 95.62 | 3.2.5 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 487 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000417 (2093 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA4598
Search term: mexD
|
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
|
Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosa.
Poole K, Gotoh N, Tsujimoto H, Zhao Q, Wada A, Yamasaki T, Neshat S, Yamagishi J, Li XZ, Nishino T
Mol Microbiol 1996 Aug;21(4):713-24
PubMed ID: 8878035
|