Pseudomonas aeruginosa PAO1, PA4646 (upp)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4646
Name
upp
Replicon chromosome
Genomic location 5212833 - 5213471 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253335.1
GI 15599841
Affymetrix PA4646_upp_at
DNASU PaCD00008015
Entrez 881277
GenBank AAG08033.1
INSDC AAG08033.1
NCBI Locus Tag PA4646
protein_id(GenBank) gb|AAG08033.1|AE004878_11|gnl|PseudoCAP|PA4646
TIGR NTL03PA04647
UniParc UPI0000137D33
UniProtKB Acc Q9HVE6
UniProtKB ID UPP_PSEAE
UniRef100 UniRef100_B7V0J2
UniRef50 UniRef50_Q7MIK2
UniRef90 UniRef90_B7V0J2

Product

Feature Type CDS
Coding Frame 1
Product Name
uracil phosphoribosyltransferase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.04
Kyte-Doolittle Hydrophobicity Value -0.002
Molecular Weight (kDa) 22.9
Isoelectric Point (pI) 6.98

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 483 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004299 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4646
Search term: upp

Human Homologs

Ensembl 110, assembly GRCh38.p14
uridine-cytidine kinase 1 like 1 [Source:HGNC Symbol;Acc:HGNC:15938]
E-value: 1.3e-12
Percent Identity: 26.7
Ensembl 110, assembly GRCh38.p14
uridine-cytidine kinase 1 like 1 [Source:HGNC Symbol;Acc:HGNC:15938]
E-value: 1.3e-12
Percent Identity: 26.7

References

Characterization of the upp gene encoding uracil phosphoribosyltransferase of Escherichia coli K12.
Andersen PS, Smith JM, Mygind B
Eur J Biochem 1992 Feb 15;204(1):51-6
PubMed ID: 1371255