Pseudomonas aeruginosa PAO1, PA4726 (cbrB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4726
Name
cbrB
Replicon chromosome
Genomic location 5306989 - 5308425 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253414.1
GI 15599920
Affymetrix PA4726_at
Entrez 881609
GenBank AAG08112.1
INSDC AAG08112.1
NCBI Locus Tag PA4726
protein_id(GenBank) gb|AAG08112.1|AE004886_4|gnl|PseudoCAP|PA4726
TIGR NTL03PA04727
UniParc UPI00000C60B1
UniProtKB Acc Q9HV73
UniProtKB ID Q9HV73_PSEAE
UniRef100 UniRef100_Q9HV73
UniRef50 UniRef50_Q9HV73
UniRef90 UniRef90_Q9HV73

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component response regulator CbrB
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -10.96
Kyte-Doolittle Hydrophobicity Value -0.242
Molecular Weight (kDa) 52.3
Isoelectric Point (pI) 5.52

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 617 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004373 (533 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4726
Search term: cbrB

Human Homologs

References

The CbrA-CbrB two-component regulatory system controls the utilization of multiple carbon and nitrogen sources in Pseudomonas aeruginosa.
Nishijyo T, Haas D, Itoh Y
Mol Microbiol 2001 May;40(4):917-31
PubMed ID: 11401699