Pseudomonas aeruginosa PAO1, PA4731 (panD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4731
Name
panD
Replicon chromosome
Genomic location 5313206 - 5313586 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253419.1
GI 15599925
Affymetrix PA4731_panD_at
Entrez 881637
GenBank AAG08117.1
INSDC AAG08117.1
NCBI Locus Tag PA4731
protein_id(GenBank) gb|AAG08117.1|AE004887_1|gnl|PseudoCAP|PA4731
TIGR NTL03PA04732
UniParc UPI00001312C2
UniProtKB Acc Q9HV68
UniProtKB ID PAND_PSEAE
UniRef100 UniRef100_Q9HV68
UniRef50 UniRef50_Q1C3V6
UniRef90 UniRef90_Q9HV68

Product

Feature Type CDS
Coding Frame 1
Product Name
aspartate 1-decarboxylase precursor
Product Name Confidence: Class 2
Synonyms aspartate alpha-decarboxylase
Evidence for Translation
Charge (pH 7) -1.39
Kyte-Doolittle Hydrophobicity Value -0.196
Molecular Weight (kDa) 13.9
Isoelectric Point (pI) 6.62

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 398 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004378 (377 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4731
Search term: panD

Human Homologs

References

Escherichia coli L-aspartate-alpha-decarboxylase: preprotein processing and observation of reaction intermediates by electrospray mass spectrometry.
Ramjee MK, Genschel U, Abell C, Smith AG
Biochem J 1997 May 1;323 ( Pt 3)(Pt 3):661-9
PubMed ID: 9169598
Crystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processing.
Albert A, Dhanaraj V, Genschel U, Khan G, Ramjee MK, Pulido R, Sibanda BL, von Delft F, Witty M, Blundell TL, Smith AG, Abell C
Nat Struct Biol 1998 Apr;5(4):289-93
PubMed ID: 9546220