Pseudomonas aeruginosa PAO1, PA4750 (folP)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4750
Name
folP
Synonym: dhpS
Replicon chromosome
Genomic location 5334921 - 5335772 (- strand)

Cross-References

RefSeq NP_253438.1
GI 15599944
Affymetrix PA4750_folP_at
Entrez 881715
GenBank AAG08136.1
INSDC AAG08136.1
NCBI Locus Tag PA4750
protein_id(GenBank) gb|AAG08136.1|AE004888_11|gnl|PseudoCAP|PA4750
TIGR NTL03PA04751
UniParc UPI00000C5DF1
UniProtKB Acc Q9HV49
UniProtKB ID Q9HV49_PSEAE
UniRef100 UniRef100_Q9HV49
UniRef50 UniRef50_Q9HV49
UniRef90 UniRef90_Q9HV49

Product

Feature Type CDS
Coding Frame 1
Product Name
dihydropteroate synthase
Product Name Confidence: Class 2
Synonyms dihydropteroate pyrophosphorylase
DHPS
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -6.40
Kyte-Doolittle Hydrophobicity Value 0.071
Molecular Weight (kDa) 30.5
Isoelectric Point (pI) 5.40

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 594 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004395 (540 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4750
Search term: folP

Human Homologs

References

Purification and partial characterization of 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase and 7,8-dihydropteroate synthase from Escherichia coli MC4100.
Talarico TL, Dev IK, Dallas WS, Ferone R, Ray PH
J Bacteriol 1991 Nov;173(21):7029-32
PubMed ID: 1657875
Cloning, sequencing, and enhanced expression of the dihydropteroate synthase gene of Escherichia coli MC4100.
Dallas WS, Gowen JE, Ray PH, Cox MJ, Dev IK
J Bacteriol 1992 Sep;174(18):5961-70
PubMed ID: 1522070