Pseudomonas aeruginosa PAO1, PA4846 (aroQ1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4846
Name
aroQ1
Synonym: aroD1
Replicon chromosome
Genomic location 5441837 - 5442280 (+ strand)

Cross-References

RefSeq NP_253533.1
GI 15600039
Affymetrix PA4846_aroQ1_at
DNASU PaCD00008103
Entrez 878093
GenBank AAG08231.1
INSDC AAG08231.1
NCBI Locus Tag PA4846
protein_id(GenBank) gb|AAG08231.1|AE004898_2|gnl|PseudoCAP|PA4846
TIGR NTL03PA04847
UniParc UPI0000126070
UniProtKB Acc O30557
UniProtKB ID AROQ1_PSEAE
UniRef100 UniRef100_O30557
UniRef50 UniRef50_O30557
UniRef90 UniRef90_O30557

Product

Feature Type CDS
Coding Frame 1
Product Name
3-dehydroquinate dehydratase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.64
Kyte-Doolittle Hydrophobicity Value -0.052
Molecular Weight (kDa) 16.2
Isoelectric Point (pI) 6.68

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4L8L LYASE 06/17/13 Crystal Structure of the Type II Dehydroquinase from Pseudomonas aeruginosa Pseudomonas aeruginosa 1.74 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 474 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004475 (533 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4846
Search term: aroQ1

Human Homologs

References

Characterization of a 3-dehydroquinase gene from Actinobacillus pleuropneumoniae with homology to the eukaryotic genes qa-2 and QUTE.
Lalonde G, O'Hanley PD, Stocker BA, Denich KT
Mol Microbiol 1994 Jan;11(2):273-80
PubMed ID: 8170389