Pseudomonas aeruginosa PAO1, PA4888 (desB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4888
Name
desB
Synonym: desB
Replicon chromosome
Genomic location 5483988 - 5485100 (- strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentDesB contributes to adaptation to high salinity by positively regulating the synthesis of osmoprotectants.

Cross-References

RefSeq NP_253575.1
GI 15600081
Affymetrix PA4888_at
Entrez 882279
GenBank AAG08273.1
INSDC AAG08273.1
NCBI Locus Tag PA4888
protein_id(GenBank) gb|AAG08273.1|AE004902_1|gnl|PseudoCAP|PA4888
TIGR NTL03PA04889
UniParc UPI00000C5E5E
UniProtKB Acc Q9HUS5
UniProtKB ID Q9HUS5_PSEAE
UniRef100 UniRef100_Q9HUS5
UniRef50 UniRef50_Q9HUS5
UniRef90 UniRef90_Q9HUS5

Product

Feature Type CDS
Coding Frame 1
Product Name
acyl-CoA delta-9-desaturase, DesB
Product Name Confidence: Class 1
Synonyms acyl-CoA delta-9-desaturase, DesB
Evidence for Translation
Charge (pH 7) 17.27
Kyte-Doolittle Hydrophobicity Value -0.239
Molecular Weight (kDa) 42.7
Isoelectric Point (pI) 10.18

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 124 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004512 (314 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4888
Search term: desB

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Two aerobic pathways for the formation of unsaturated fatty acids in Pseudomonas aeruginosa.
Zhu K, Choi KH, Schweizer HP, Rock CO, Zhang YM
Mol Microbiol 2006 Apr;60(2):260-73
PubMed ID: 16573679
Pseudomonas aeruginosa DesB Promotes Staphylococcus aureus Growth Inhibition in Coculture by Controlling the Synthesis of HAQs.
Kim S, Yoon Y, Choi KH
PLoS One 2015;10(7):e0134624
PubMed ID: 26230088
Role of Pseudomonas aeruginosa DesB in Adaptation to Osmotic Stress.
Kim S, Ha J, Lee H, Lee S, Lee J, Choi Y, Oh H, Yoon Y, Choi KH
J Food Prot 2019 Aug;82(8):1278-1282
PubMed ID: 31298570