Pseudomonas aeruginosa PAO1, PA4898 (opdK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4898
Name
opdK
Synonym: opdK
Replicon chromosome
Genomic location 5494460 - 5495713 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_253585.1
GI 15600091
Affymetrix PA4898_at
Entrez 879748
GenBank AAG08283.1
INSDC AAG08283.1
NCBI Locus Tag PA4898
protein_id(GenBank) gb|AAG08283.1|AE004903_1|gnl|PseudoCAP|PA4898
TIGR NTL03PA04899
UniParc UPI00000C5E68
UniProtKB Acc Q9HUR5
UniProtKB ID Q9HUR5_PSEAE
UniRef100 UniRef100_Q9HUR5
UniRef50 UniRef50_Q9HUR5
UniRef90 UniRef90_Q9HUR5

Product

Feature Type CDS
Coding Frame 1
Product Name
histidine porin OpdK
Product Name Confidence: Class 1
Synonyms vanillate porin OpdK
Evidence for Translation
Charge (pH 7) 1.90
Kyte-Doolittle Hydrophobicity Value -0.371
Molecular Weight (kDa) 45.8
Isoelectric Point (pI) 7.79

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Outer Membrane Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2QTK MEMBRANE PROTEIN 08/02/07 Crystal Structure of the outer membrane protein opdK from Pseudomonas aeruginosa Pseudomonas aeruginosa 2.8 X-RAY DIFFRACTION 100.0
3SYS MEMBRANE PROTEIN 07/18/11 Improved crystal structure of Pseudomonas aeruginosa OccK1 (OpdK) Pseudomonas aeruginosa 1.65 X-RAY DIFFRACTION 100.0
2Y2X MEMBRANE PROTEIN 12/16/10 Crystal Structure of Pseudomonas Aeruginosa OpdK with Vanillate PSEUDOMONAS AERUGINOSA PA01 1.65 X-RAY DIFFRACTION 100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
(Hydroxyethyloxy)Tri(Ethyloxy)Octane DB04233 DrugBank 5.1.4 Q9HUR5 Vanillate porin OpdK 100.0 417 8.2e-245

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 19 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000239 (1158 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4898
Search term: opdK

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295