Pseudomonas aeruginosa PAO1, PA4937 (rnr)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4937
Name
rnr
Synonym: vacB
Replicon chromosome
Genomic location 5538696 - 5541410 (- strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253624.1
GI 15600130
Affymetrix PA4937_rnr_at
Entrez 879988
GenBank AAG08322.1
INSDC AAG08322.1
NCBI Locus Tag PA4937
protein_id(GenBank) gb|AAG08322.1|AE004906_10|gnl|PseudoCAP|PA4937
TIGR NTL03PA04938
UniParc UPI00000C5E86
UniProtKB Acc Q9HUM7
UniProtKB ID Q9HUM7_PSEAE
UniRef100 UniRef100_Q9HUM7
UniRef50 UniRef50_Q4KJ64
UniRef90 UniRef90_Q9HUM7

Product

Feature Type CDS
Coding Frame 1
Product Name
exoribonuclease RNase R
Product Name Confidence: Class 2
Synonyms virulence protein VacB
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 18.14
Kyte-Doolittle Hydrophobicity Value -0.478
Molecular Weight (kDa) 100.1
Isoelectric Point (pI) 9.37

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 540 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004552 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4937
Search term: rnr

Human Homologs

Ensembl 110, assembly GRCh38.p14
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [Source:HGNC Symbol;Acc:HGNC:20604]
E-value: 6.1e-48
Percent Identity: 32.2
Ensembl 110, assembly GRCh38.p14
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [Source:HGNC Symbol;Acc:HGNC:20604]
E-value: 6.1e-48
Percent Identity: 32.2
Ensembl 110, assembly GRCh38.p14
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [Source:HGNC Symbol;Acc:HGNC:20604]
E-value: 6.1e-48
Percent Identity: 32.2

References

vacB, a novel chromosomal gene required for expression of virulence genes on the large plasmid of Shigella flexneri.
Tobe T, Sasakawa C, Okada N, Honma Y, Yoshikawa M
J Bacteriol 1992 Oct;174(20):6359-67
PubMed ID: 1400189
The vacB gene required for virulence in Shigella flexneri and Escherichia coli encodes the exoribonuclease RNase R.
Cheng ZF, Zuo Y, Li Z, Rudd KE, Deutscher MP
J Biol Chem 1998 Jun 5;273(23):14077-80
PubMed ID: 9603904