Pseudomonas aeruginosa PAO1, PA4946 (mutL)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4946
Name
mutL
Replicon chromosome
Genomic location 5549780 - 5551681 (- strand)
Transposon Mutants 10 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253633.1
GI 15600139
Affymetrix PA4946_mutL_at
Entrez 878468
GenBank AAG08331.1
INSDC AAG08331.1
NCBI Locus Tag PA4946
protein_id(GenBank) gb|AAG08331.1|AE004907_9|gnl|PseudoCAP|PA4946
TIGR NTL03PA04947
UniParc UPI000012FA4B
UniProtKB Acc Q9HUL8
UniProtKB ID MUTL_PSEAE
UniRef100 UniRef100_B7V209
UniRef50 UniRef50_Q88DD1
UniRef90 UniRef90_A6VD59

Product

Feature Type CDS
Coding Frame 1
Product Name
DNA mismatch repair protein MutL
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.26
Kyte-Doolittle Hydrophobicity Value -0.282
Molecular Weight (kDa) 69.7
Isoelectric Point (pI) 6.52

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 519 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004561 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4946
Search term: mutL

Human Homologs

Ensembl 110, assembly GRCh38.p14
mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127]
E-value: 1.1e-48
Percent Identity: 35.7
Ensembl 110, assembly GRCh38.p14
mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127]
E-value: 1.1e-48
Percent Identity: 35.7
Ensembl 110, assembly GRCh38.p14
mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127]
E-value: 1.1e-48
Percent Identity: 35.7
Ensembl 110, assembly GRCh38.p14
mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127]
E-value: 1.1e-48
Percent Identity: 35.7
Ensembl 110, assembly GRCh38.p14
mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127]
E-value: 1.1e-48
Percent Identity: 35.7
Ensembl 110, assembly GRCh38.p14
mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127]
E-value: 1.1e-48
Percent Identity: 35.7
Ensembl 110, assembly GRCh38.p14
mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127]
E-value: 1.1e-48
Percent Identity: 35.7
Ensembl 110, assembly GRCh38.p14
mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127]
E-value: 1.1e-48
Percent Identity: 35.7

References

Nucleotide sequence of the Salmonella typhimurium mutL gene required for mismatch repair: homology of MutL to HexB of Streptococcus pneumoniae and to PMS1 of the yeast Saccharomyces cerevisiae.
Mankovich JA, McIntyre CA, Walker GC
J Bacteriol 1989 Oct;171(10):5325-31
PubMed ID: 2676972
The mutL repair gene of Escherichia coli K-12 forms a superoperon with a gene encoding a new cell-wall amidase.
Tsui HC, Zhao G, Feng G, Leung HC, Winkler ME
Mol Microbiol 1994 Jan;11(1):189-202
PubMed ID: 7511774