Pseudomonas aeruginosa PAO1, PA4969 (cpdA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4969
Name
cpdA
Synonym: icc
Replicon chromosome
Genomic location 5578681 - 5579499 (- strand)

Cross-References

RefSeq NP_253656.1
GI 15600162
Affymetrix PA4969_at
Entrez 880028
GenBank AAG08354.1
INSDC AAG08354.1
NCBI Locus Tag PA4969
protein_id(GenBank) gb|AAG08354.1|AE004910_1|gnl|PseudoCAP|PA4969
TIGR NTL03PA04970
UniParc UPI00000C5EA0
UniProtKB Acc Q9HUJ6
UniProtKB ID Q9HUJ6_PSEAE
UniRef100 UniRef100_W0Z132
UniRef50 UniRef50_D4P095
UniRef90 UniRef90_D4P095

Product

Feature Type CDS
Coding Frame 1
Product Name
Cyclic AMP (cAMP) Phosphodiesterase, CpdA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -13.65
Kyte-Doolittle Hydrophobicity Value -0.293
Molecular Weight (kDa) 30.5
Isoelectric Point (pI) 4.75

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 202 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004584 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4969
Search term: cpdA

Human Homologs

References

In vitro and in vivo characterization of the Pseudomonas aeruginosa cyclic AMP (cAMP) phosphodiesterase CpdA, required for cAMP homeostasis and virulence factor regulation.
Fuchs EL, Brutinel ED, Klem ER, Fehr AR, Yahr TL, Wolfgang MC
J Bacteriol 2010 Jun;192(11):2779-90
PubMed ID: 20348254