Pseudomonas aeruginosa PAO1, PA4990

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4990
Name
Replicon chromosome
Genomic location 5606103 - 5606435 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253677.1
GI 15600183
Affymetrix PA4990_at
DNASU PaCD00008155
Entrez 880147
GenBank AAG08375.1
INSDC AAG08375.1
NCBI Locus Tag PA4990
protein_id(GenBank) gb|AAG08375.1|AE004912_1|gnl|PseudoCAP|PA4990
TIGR NTL03PA04991
UniParc UPI00000C5EB3
UniProtKB Acc Q9HUH5
UniProtKB ID MTDTR_PSEAE
UniRef100 UniRef100_Q9HUH5
UniRef50 UniRef50_Q9HUH5
UniRef90 UniRef90_Q9HUH5

Product

Feature Type CDS
Coding Frame 1
Product Name
SMR multidrug efflux transporter
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 3.21
Kyte-Doolittle Hydrophobicity Value 1.444
Molecular Weight (kDa) 11.5
Isoelectric Point (pI) 9.86

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
Pseudomonas aeruginosa emrE EmrE is a small multidrug transporter that functions as a homodimer and that couples the efflux of small polyaromatic cations from the cell with the import of protons down an electrochemical gradient. Confers resistance to tetraphenylphosphonium, methyl viologen, gentamicin, kanamycin, and neomycin. [PMID:12499164] ARO:3004038 protein homolog model Perfect 194.5 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 309 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004600 (529 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4990

Human Homologs

References

The 3' conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants.
Paulsen IT, Littlejohn TG, Rådström P, Sundström L, Sköld O, Swedberg G, Skurray RA
Antimicrob Agents Chemother 1993 Apr;37(4):761-8
PubMed ID: 8494372