Pseudomonas aeruginosa PAO1, PA5103 (puuR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5103
Name
puuR
Replicon chromosome
Genomic location 5746849 - 5747871 (- strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentCorrected typo. Gene originally entered in database as pauR. Regulatory role note demonstrated in P. aeruginosa.

Cross-References

RefSeq NP_253790.1
GI 15600296
Affymetrix PA5103_at
Entrez 883032
GenBank AAG08488.1
INSDC AAG08488.1
NCBI Locus Tag PA5103
protein_id(GenBank) gb|AAG08488.1|AE004923_4|gnl|PseudoCAP|PA5103
TIGR NTL03PA05104
UniParc UPI00000C5F01
UniProtKB Acc Q9HU80
UniProtKB ID Q9HU80_PSEAE
UniRef100 UniRef100_Q9HU80
UniRef50 UniRef50_Q9HU80
UniRef90 UniRef90_Q9HU80

Product

Feature Type CDS
Coding Frame 1
Product Name
PuuR
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -2.15
Kyte-Doolittle Hydrophobicity Value -0.316
Molecular Weight (kDa) 37.9
Isoelectric Point (pI) 6.17

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 2
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 118 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004699 (489 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5103
Search term: puuR
Search term: PuuR

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Purification and characterization of a glycine betaine binding protein from Escherichia coli.
Barron A, Jung JU, Villarejo M
J Biol Chem 1987 Aug 25;262(24):11841-6
PubMed ID: 3305496
Functional characterization of seven γ-Glutamylpolyamine synthetase genes and the bauRABCD locus for polyamine and β-Alanine utilization in Pseudomonas aeruginosa PAO1.
Yao X, He W, Lu CD
J. Bacteriol. 2011 Aug;193(15):3923-30
PubMed ID: 21622750