Pseudomonas aeruginosa PAO1, PA5159

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5159
Name
Synonym: emrA
Synonym: pmrA
Replicon chromosome
Genomic location 5807173 - 5808357 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253846.1
GI 15600352
Affymetrix PA5159_at
Entrez 880006
GenBank AAG08544.1
INSDC AAG08544.1
NCBI Locus Tag PA5159
protein_id(GenBank) gb|AAG08544.1|AE004928_10|gnl|PseudoCAP|PA5159
TIGR NTL03PA05160
UniParc UPI00000C5F31
UniProtKB Acc Q9HU25
UniProtKB ID Q9HU25_PSEAE
UniRef100 UniRef100_Q9HU25
UniRef50 UniRef50_Q63TQ2
UniRef90 UniRef90_Q02EK6

Product

Feature Type CDS
Coding Frame 1
Product Name
multidrug resistance protein
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -2.82
Kyte-Doolittle Hydrophobicity Value -0.315
Molecular Weight (kDa) 43.2
Isoelectric Point (pI) 6.44

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 390 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004751 (498 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5159

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Emr, an Escherichia coli locus for multidrug resistance.
Lomovskaya O, Lewis K
Proc Natl Acad Sci U S A 1992 Oct 1;89(19):8938-42
PubMed ID: 1409590