Pseudomonas aeruginosa PAO1, PA5254

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5254
Name
Synonym: fkl
Synonym: fkbZ
Replicon chromosome
Genomic location 5916227 - 5916856 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253941.1
GI 15600447
Affymetrix PA5254_at
Entrez 880807
GenBank AAG08639.1
INSDC AAG08639.1
NCBI Locus Tag PA5254
protein_id(GenBank) gb|AAG08639.1|AE004938_1|gnl|PseudoCAP|PA5254
TIGR NTL03PA05255
UniParc UPI000012A833
UniProtKB Acc P30417
UniProtKB ID FKBZ_PSEAE
UniRef100 UniRef100_P30417
UniRef50 UniRef50_P30417
UniRef90 UniRef90_P30417

Product

Feature Type CDS
Coding Frame 1
Product Name
probable peptidyl-prolyl cis-trans isomerase, FkbP-type
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) -3.28
Kyte-Doolittle Hydrophobicity Value -0.069
Molecular Weight (kDa) 23.0
Isoelectric Point (pI) 5.37

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Outer Membrane Class 2
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 345 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004835 (488 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5254

Human Homologs

Ensembl 110, assembly GRCh38.p14
FKBP prolyl isomerase 4 [Source:HGNC Symbol;Acc:HGNC:3720]
E-value: 1.9e-08
Percent Identity: 36.4

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295