Pseudomonas aeruginosa PAO1, PA5262 (fimS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5262
Name
fimS
Synonym: fimS
Replicon chromosome
Genomic location 5923295 - 5924371 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentRemoved AlgZ from name to reflect fact that mutants in this gene do not lose ability to produce alginate. Preferred name changed to FimS.

Cross-References

RefSeq NP_253949.1
GI 15600455
Affymetrix PA5262_algZ_at
DNASU PaCD00008270
Entrez 879635
GenBank AAG08647.1
INSDC AAG08647.1
NCBI Locus Tag PA5262
protein_id(GenBank) gb|AAG08647.1|AE004938_9|gnl|PseudoCAP|PA5262
TIGR NTL03PA05263
UniParc UPI00000D422F
UniProtKB Acc G3XCZ2
UniProtKB ID G3XCZ2_PSEAE
UniRef100 UniRef100_W0Z376
UniRef50 UniRef50_Q48QD4
UniRef90 UniRef90_A6VE39

Product

Feature Type CDS
Coding Frame 1
Product Name
FimS
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 1.44
Kyte-Doolittle Hydrophobicity Value 0.241
Molecular Weight (kDa) 40.1
Isoelectric Point (pI) 7.44

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Cytoplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0091
Category Alginate regulation
Evidence
Host Organism
Notes
Reference

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 316 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004843 (379 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5262
Search term: fimS
Search term: FimS

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Identification of the algZ gene upstream of the response regulator algR and its participation in control of alginate production in Pseudomonas aeruginosa.
Yu H, Mudd M, Boucher JC, Schurr MJ, Deretic V
J Bacteriol 1997 Jan;179(1):187-93
PubMed ID: 8981997