Pseudomonas aeruginosa PAO1, PA5280 (sss)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5280
Name
sss
Synonym: xerC
Replicon chromosome
Genomic location 5944327 - 5945238 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253967.1
GI 15600473
Affymetrix PA5280_sss_at
DNASU PaCD00008282
Entrez 878328
GenBank AAG08665.1
INSDC AAG08665.1
NCBI Locus Tag PA5280
protein_id(GenBank) gb|AAG08665.1|AE004940_9|gnl|PseudoCAP|PA5280
TIGR NTL03PA05281
UniParc UPI00000C5F84
UniProtKB Acc Q51566
UniProtKB ID XERC_PSEAE
UniRef100 UniRef100_Q51566
UniRef50 UniRef50_Q51566
UniRef90 UniRef90_Q51566

Product

Feature Type CDS
Coding Frame 1
Product Name
site-specific recombinase Sss
Product Name Confidence: Class 1
Synonyms site-specific recombinase XerC
Evidence for Translation
Charge (pH 7) 13.10
Kyte-Doolittle Hydrophobicity Value -0.472
Molecular Weight (kDa) 33.9
Isoelectric Point (pI) 10.47

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 620 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004858 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5280
Search term: sss

Human Homologs

References

The sss gene product, which affects pyoverdin production in Pseudomonas aeruginosa 7NSK2, is a site-specific recombinase.
Höfte M, Dong Q, Kourambas S, Krishnapillai V, Sherratt D, Mergeay M
Mol Microbiol 1994 Dec;14(5):1011-20
PubMed ID: 7715441
A site-specific recombinase is required for competitive root colonization by Pseudomonas fluorescens WCS365.
Dekkers LC, Phoelich CC, van der Fits L, Lugtenberg BJ
Proc Natl Acad Sci U S A 1998 Jun 9;95(12):7051-6
PubMed ID: 9618537