Pseudomonas aeruginosa PAO1, PA5326 (sphD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5326
Name
sphD
Replicon chromosome
Genomic location 5997057 - 5998265 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_254013.1
GI 15600519
Affymetrix PA5326_at
Entrez 880924
GenBank AAG08711.1
NCBI Locus Tag PA5326
protein_id(GenBank) gb|AAG08711.1|AE004945_5|gnl|PseudoCAP|PA5326
TIGR NTL03PA05327
UniProtKB Acc Q9HTM9
UniProtKB ID Q9HTM9_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
SphD
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 3.62
Kyte-Doolittle Hydrophobicity Value -0.139
Molecular Weight (kDa) 44.6
Isoelectric Point (pI) 8.40

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 32 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004895 (351 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5326
Search term: sphD
Search term: SphD

Human Homologs

References

Detection of host-derived sphingosine by Pseudomonas aeruginosa is important for survival in the murine lung.
LaBauve AE, Wargo MJ
PLoS Pathog 2014 Jan;10(1):e1003889
PubMed ID: 24465209