Pseudomonas aeruginosa PAO1, PA5362

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5362
Name
Replicon chromosome
Genomic location 6028976 - 6030316 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_254049.1
GI 15600555
Affymetrix PA5362_at
Entrez 878512
GenBank AAG08747.1
INSDC AAG08747.1
NCBI Locus Tag PA5362
protein_id(GenBank) gb|AAG08747.1|AE004948_3|gnl|PseudoCAP|PA5362
TIGR NTL03PA05363
UniParc UPI00000C5FC3
UniProtKB Acc Q9HTJ8
UniProtKB ID Q9HTJ8_PSEAE
UniRef100 UniRef100_W0Z3H0
UniRef50 UniRef50_Q88C61
UniRef90 UniRef90_A6VEH2

Product

Feature Type CDS
Coding Frame 1
Product Name
conserved hypothetical protein
Product Name Confidence: Class 4
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -11.68
Kyte-Doolittle Hydrophobicity Value 0.168
Molecular Weight (kDa) 50.0
Isoelectric Point (pI) 5.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 596 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004927 (533 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5362

Human Homologs

Ensembl 110, assembly GRCh38.p14
cyclin and CBS domain divalent metal cation transport mediator 2 [Source:HGNC Symbol;Acc:HGNC:103]
E-value: 6.5e-11
Percent Identity: 25.1
Ensembl 110, assembly GRCh38.p14
cyclin and CBS domain divalent metal cation transport mediator 2 [Source:HGNC Symbol;Acc:HGNC:103]
E-value: 6.5e-11
Percent Identity: 25.1

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295