Pseudomonas aeruginosa PAO1, PA5385 (cdhB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5385
Name
cdhB
Replicon chromosome
Genomic location 6063353 - 6063832 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentTransposon insertion into cdhB results in a strain unable to grow using L-carnitine as a sole carbon source. The specific function of CdhB in carnitine catabolism is not known but bioinformatic analysis supports the strong conservation of the cdhCAB genes in all species known to aerobically catabolize L-carnitine.

Cross-References

RefSeq NP_254072.1
GI 15600578
Affymetrix PA5385_at
DNASU PaCD00008328
Entrez 881644
GenBank AAG08770.1
INSDC AAG08770.1
NCBI Locus Tag PA5385
protein_id(GenBank) gb|AAG08770.1|AE004951_4|gnl|PseudoCAP|PA5385
TIGR NTL03PA05386
UniParc UPI00000C5FD6
UniProtKB Acc Q9HTH9
UniProtKB ID Q9HTH9_PSEAE
UniRef100 UniRef100_Q9HTH9
UniRef50 UniRef50_W4NVN7
UniRef90 UniRef90_Q9HTH9

Product

Feature Type CDS
Coding Frame 1
Product Name
CdhB, Carnitine dehydrogenase-related gene B
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -3.40
Kyte-Doolittle Hydrophobicity Value -0.053
Molecular Weight (kDa) 17.6
Isoelectric Point (pI) 6.43

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 51 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004944 (484 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5385
Search term: cdhB

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295