Pseudomonas aeruginosa PAO1, PA5425 (purK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA5425
Name
purK
Replicon chromosome
Genomic location 6105159 - 6106241 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_254112.1
GI 15600618
Affymetrix PA5425_purK_at
Entrez 878440
GenBank AAG08810.1
INSDC AAG08810.1
NCBI Locus Tag PA5425
protein_id(GenBank) gb|AAG08810.1|AE004955_4|gnl|PseudoCAP|PA5425
TIGR NTL03PA05426
UniParc UPI0000132B22
UniProtKB Acc P72158
UniProtKB ID PURK_PSEAE
UniRef100 UniRef100_P72158
UniRef50 UniRef50_P72158
UniRef90 UniRef90_P72158

Product

Feature Type CDS
Coding Frame 1
Product Name
phosphoribosylaminoimidazole carboxylase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -10.26
Kyte-Doolittle Hydrophobicity Value 0.082
Molecular Weight (kDa) 38.5
Isoelectric Point (pI) 5.38

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 492 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004978 (552 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5425
Search term: purK

References

Large-scale isolation of candidate virulence genes of Pseudomonas aeruginosa by in vivo selection.
Wang J, Mushegian A, Lory S, Jin S
Proc. Natl. Acad. Sci. U.S.A. 1996 Sep;93(19):10434-9
PubMed ID: 8816818