Pseudomonas aeruginosa PAO1, PA5495 (thrB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA5495
Name
thrB
Replicon chromosome
Genomic location 6186927 - 6187877 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_254182.1
GI 15600688
Affymetrix PA5495_thrB_at
Entrez 877825
GenBank AAG08880.1
INSDC AAG08880.1
NCBI Locus Tag PA5495
protein_id(GenBank) gb|AAG08880.1|AE004962_4|gnl|PseudoCAP|PA5495
TIGR NTL03PA05496
UniParc UPI000012DE29
UniProtKB Acc P29364
UniProtKB ID KHSE_PSEAE
UniRef100 UniRef100_P29364
UniRef50 UniRef50_P29364
UniRef90 UniRef90_P29364

Product

Feature Type CDS
Coding Frame 1
Product Name
homoserine kinase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -9.22
Kyte-Doolittle Hydrophobicity Value -0.109
Molecular Weight (kDa) 35.4
Isoelectric Point (pI) 5.56

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 132 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG005034 (553 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5495
Search term: thrB
Search term: homoserine kinase

References

Isolation, organization and expression of the Pseudomonas aeruginosa threonine genes.
Clepet C, Borne F, Krishnapillai V, Baird C, Patte JC, Cami B
Mol. Microbiol. 1992 Nov;6(21):3109-19
PubMed ID: 1333566
ThrH, a homoserine kinase isozyme with in vivo phosphoserine phosphatase activity in Pseudomonas aeruginosa.
Patte JC, Clepet C, Bally M, Borne F, Méjean V, Foglino M
Microbiology (Reading, Engl.) 1999 Apr;145 ( Pt 4)
PubMed ID: 10220164