Pseudomonas aeruginosa PAO1, PA0178

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0178
Name
Replicon chromosome
Genomic location 202147 - 204066 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_248868.1
GI 15595376
Affymetrix PA0178_at
Entrez 878420
GenBank AAG03568.1
INSDC AAG03568.1
NCBI Locus Tag PA0178
protein_id(GenBank) gb|AAG03568.1|AE004455_9|gnl|PseudoCAP|PA0178
TIGR NTL03PA00179
UniParc UPI00000C4F80
UniProtKB Acc Q9I6V4
UniProtKB ID Q9I6V4_PSEAE
UniRef100 UniRef100_Q9I6V4
UniRef50 UniRef50_Q02UQ0
UniRef90 UniRef90_Q02UQ0

Product

Feature Type CDS
Coding Frame 1
Product Name
probable two-component sensor
Product Name Confidence: Class 3
Synonyms probable chemotaxis protein sensory transduction histidine kinase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -37.63
Kyte-Doolittle Hydrophobicity Value -0.121
Molecular Weight (kDa) 68.9
Isoelectric Point (pI) 4.52

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 399 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000176 (378 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0178

References

CheA protein, a central regulator of bacterial chemotaxis, belongs to a family of proteins that control gene expression in response to changing environmental conditions.
Stock A, Chen T, Welsh D, Stock J
Proc. Natl. Acad. Sci. U.S.A. 1988 Mar;85(5):1403-7
PubMed ID: 3278311
Structure of CheA, a signal-transducing histidine kinase.
Bilwes AM, Alex LA, Crane BR, Simon MI
Cell 1999 Jan;96(1):131-41
PubMed ID: 9989504