Pseudomonas aeruginosa PAO1, PA0399

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0399
Name
Replicon chromosome
Genomic location 440638 - 442011 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249090.1
GI 15595596
Affymetrix PA0399_at
Entrez 878291
GenBank AAG03788.1
INSDC AAG03788.1
NCBI Locus Tag PA0399
protein_id(GenBank) gb|AAG03788.1|AE004477_5|gnl|PseudoCAP|PA0399
TIGR NTL03PA00400
UniParc UPI00000C5041
UniProtKB Acc Q9I6A1
UniProtKB ID Q9I6A1_PSEAE
UniRef100 UniRef100_W0YLM6
UniRef50 UniRef50_B6INW1
UniRef90 UniRef90_Q02U13

Product

Feature Type CDS
Coding Frame 1
Product Name
cystathionine beta-synthase
Product Name Confidence: Class 2
Synonyms methylcysteine synthase
beta-thionase
serine sulfhydrase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -8.70
Kyte-Doolittle Hydrophobicity Value -0.078
Molecular Weight (kDa) 49.2
Isoelectric Point (pI) 5.48

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 623 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000390 (386 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0399

Human Homologs

Ensembl 97, assembly GRCh38.p12
cystathionine-beta-synthase [Source:HGNC Symbol;Acc:HGNC:1550]
E-value: 5.5e-70
Percent Identity: 34.6

Human Homologs

Ensembl 97, assembly GRCh38.p12
cystathionine-beta-synthase like [Source:HGNC Symbol;Acc:HGNC:51829]
E-value: 5.5e-70
Percent Identity: 34.6

Human Homologs

Ensembl 97, assembly GRCh38.p12
cystathionine-beta-synthase [Source:HGNC Symbol;Acc:HGNC:1550]
E-value: 5.5e-70
Percent Identity: 34.6

Human Homologs

Ensembl 97, assembly GRCh38.p12
cystathionine-beta-synthase like [Source:HGNC Symbol;Acc:HGNC:51829]
E-value: 5.5e-70
Percent Identity: 34.6

Human Homologs

Ensembl 97, assembly GRCh38.p12
cystathionine-beta-synthase like [Source:HGNC Symbol;Acc:HGNC:51829]
E-value: 5.5e-70
Percent Identity: 34.6

Human Homologs

Ensembl 97, assembly GRCh38.p12
cystathionine-beta-synthase [Source:HGNC Symbol;Acc:HGNC:1550]
E-value: 5.5e-70
Percent Identity: 34.6

Human Homologs

Ensembl 97, assembly GRCh38.p12
cystathionine-beta-synthase [Source:HGNC Symbol;Acc:HGNC:1550]
E-value: 5.5e-70
Percent Identity: 34.6

Human Homologs

Ensembl 97, assembly GRCh38.p12
cystathionine-beta-synthase like [Source:HGNC Symbol;Acc:HGNC:51829]
E-value: 5.5e-70
Percent Identity: 34.6

References

Human cystathionine beta-synthase cDNA: sequence, alternative splicing and expression in cultured cells.
Kraus JP, Le K, Swaroop M, Ohura T, Tahara T, Rosenberg LE, Roper MD, Kozich V
Hum. Mol. Genet. 1993 Oct;2(10):1633-8
PubMed ID: 7903580
An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae.
Philipp WJ, Poulet S, Eiglmeier K, Pascopella L, Balasubramanian V, Heym B, Bergh S, Bloom BR, Jacobs WR, Cole ST
Proc. Natl. Acad. Sci. U.S.A. 1996 Apr;93(7):3132-7
PubMed ID: 8610181