Pseudomonas aeruginosa PAO1, PA0401

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0401
Name
Synonym: pyrC'
Synonym: pyrX
Replicon chromosome
Genomic location 443419 - 444690 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_249092.1
GI 15595598
Affymetrix PA0401_at
Entrez 878275
GenBank AAG03790.1
INSDC AAG03790.1
NCBI Locus Tag PA0401
protein_id(GenBank) gb|AAG03790.1|AE004477_7|gnl|PseudoCAP|PA0401
TIGR NTL03PA00402
UniParc UPI0000132E1D
UniProtKB Acc Q51551
UniProtKB ID PYRX_PSEAE
UniRef100 UniRef100_Q51551
UniRef50 UniRef50_Q51551
UniRef90 UniRef90_Q51551

Product

Feature Type CDS
Coding Frame 1
Product Name
noncatalytic dihydroorotase-like protein
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -8.26
Kyte-Doolittle Hydrophobicity Value 0.103
Molecular Weight (kDa) 44.1
Isoelectric Point (pI) 5.75

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 583 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000392 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0401

Human Homologs

References

Aspartate transcarbamoylase genes of Pseudomonas putida: requirement for an inactive dihydroorotase for assembly into the dodecameric holoenzyme.
Schurr MJ, Vickrey JF, Kumar AP, Campbell AL, Cunin R, Benjamin RC, Shanley MS, O'Donovan GA
J Bacteriol 1995 Apr;177(7):1751-9
PubMed ID: 7896697
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994