Pseudomonas aeruginosa PAO1, PA0582 (folB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0582
Name
folB
Replicon chromosome
Genomic location 641073 - 641426 (+ strand)

Cross-References

RefSeq NP_249273.1
GI 15595779
Affymetrix PA0582_folB_at
DNASU PaCD00006255
Entrez 880775
GenBank AAG03971.1
INSDC AAG03971.1
NCBI Locus Tag PA0582
protein_id(GenBank) gb|AAG03971.1|AE004494_7|gnl|PseudoCAP|PA0582
TIGR NTL03PA00583
UniParc UPI00000C50C6
UniProtKB Acc Q9I5V5
UniProtKB ID Q9I5V5_PSEAE
UniRef100 UniRef100_Q9I5V5
UniRef50 UniRef50_A6UZ85
UniRef90 UniRef90_A6UZ85

Product

Feature Type CDS
Coding Frame 1
Product Name
dihydroneopterin aldolase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -4.83
Kyte-Doolittle Hydrophobicity Value -0.054
Molecular Weight (kDa) 13.1
Isoelectric Point (pI) 4.64

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 290 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000565 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0582
Search term: folB

Human Homologs

References

Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase.
Haussmann C, Rohdich F, Schmidt E, Bacher A, Richter G
J Biol Chem 1998 Jul 10;273(28):17418-24
PubMed ID: 9651328