Pseudomonas aeruginosa PAO1, PA0609 (trpE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0609
Name
trpE
Replicon chromosome
Genomic location 670980 - 672458 (+ strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_249300.1
GI 15595806
Affymetrix PA0609_trpE_at
Entrez 879191
GenBank AAG03998.1
INSDC BAA02200.1
NCBI Locus Tag PA0609
protein_id(GenBank) gb|AAG03998.1|AE004497_5|gnl|PseudoCAP|PA0609
TIGR NTL03PA00610
UniParc UPI00001375C8
UniProtKB Acc P20580
UniProtKB ID TRPE_PSEAE
UniRef100 UniRef100_P20580
UniRef50 UniRef50_P20580
UniRef90 UniRef90_P20580

Product

Feature Type CDS
Coding Frame 1
Product Name
anthranilate synthetase component I
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -16.71
Kyte-Doolittle Hydrophobicity Value -0.105
Molecular Weight (kDa) 54.6
Isoelectric Point (pI) 4.72

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 598 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000592 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0609
Search term: trpE

Human Homologs

References

DNA sequences and characterization of four early genes of the tryptophan pathway in Pseudomonas aeruginosa.
Essar DW, Eberly L, Han CY, Crawford IP
J Bacteriol 1990 Feb;172(2):853-66
PubMed ID: 2105306