Pseudomonas aeruginosa PAO1, PA0743

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0743
Name
Replicon chromosome
Genomic location 810275 - 811171 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249434.1
GI 15595940
Affymetrix PA0743_at
Entrez 882135
GenBank AAG04132.1
INSDC AAG04132.1
NCBI Locus Tag PA0743
protein_id(GenBank) gb|AAG04132.1|AE004509_7|gnl|PseudoCAP|PA0743
TIGR NTL03PA00744
UniParc UPI00000C5132
UniProtKB Acc Q9I5I6
UniProtKB ID SERDH_PSEAE
UniRef100 UniRef100_Q9I5I6
UniRef50 UniRef50_Q9I5I6
UniRef90 UniRef90_Q9I5I6

Product

Feature Type CDS
Coding Frame 1
Product Name
probable 3-hydroxyisobutyrate dehydrogenase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) -4.86
Kyte-Doolittle Hydrophobicity Value 0.237
Molecular Weight (kDa) 30.8
Isoelectric Point (pI) 5.31

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3OBB OXIDOREDUCTASE 08/06/10 Crystal structure of a possible 3-hydroxyisobutyrate Dehydrogenase from pseudomonas aeruginosa pao1 PSEUDOMONAS AERUGINOSA 2.2 X-RAY DIFFRACTION 100.0
3Q3C OXIDOREDUCTASE 12/21/10 Crystal structure of a serine dehydrogenase from Pseudomonas aeruginosa pao1 in complex with NAD PSEUDOMONAS AERUGINOSA 2.299 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 488 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000717 (850 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0743

Human Homologs

Ensembl 97, assembly GRCh38.p12
3-hydroxyisobutyrate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:4907]
E-value: 1.1e-63
Percent Identity: 44.9

References

No references are associated with this feature.