Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA0762
|
Name |
algU
Synonym: algT |
Replicon | chromosome |
Genomic location | 831301 - 831882 (+ strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
RefSeq | NP_249453.1 |
GI | 15595959 |
Affymetrix | PA0762_algU_at |
DNASU | PaCD00006350 |
Entrez | 882125 |
GenBank | AAG04151.1 |
INSDC | AAA92355.1 |
NCBI Locus Tag | PA0762 |
protein_id(GenBank) | gb|AAG04151.1|AE004511_4|gnl|PseudoCAP|PA0762 |
TIGR | NTL03PA00763 |
UniParc | UPI000013484A |
UniProtKB Acc | Q06198 |
UniProtKB ID | RPSH_PSEAE |
UniRef100 | UniRef100_Q06198 |
UniRef50 | UniRef50_D0ZSY9 |
UniRef90 | UniRef90_Q06198 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
sigma factor AlgU
|
Synonyms |
sigma factor AlgT |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -4.83 |
Kyte-Doolittle Hydrophobicity Value | -0.428 |
Molecular Weight (kDa) | 22.2 |
Isoelectric Point (pI) | 5.38 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
6IN7 | TRANSCRIPTION | 10/24/18 | Crystal structure of AlgU in complex with MucA(cyto) | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 1.96 | X-RAY DIFFRACTION | 100.0 |
Source 1 | |
Database | Victors : 4262 |
Category | Alginate regulation |
Evidence |
ECO:0000015
mutant phenotype evidence
|
Host Organism | Rattus norvegicus |
Notes | |
Infection model | Rat agar bead model of chronic lung infection |
Reference | 14641575 |
Source 2 | |
Database | VFDB : VF0091 |
Category | Alginate regulation |
Evidence |
|
Host Organism | |
Notes | |
Reference |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 495 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000736 (532 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA0762
Search term: algU
Search term: sigma factor AlgU
|
Functional equivalence of Escherichia coli sigma E and Pseudomonas aeruginosa AlgU: E. coli rpoE restores mucoidy and reduces sensitivity to reactive oxygen intermediates in algU mutants of P. aeruginosa.
Yu H, Schurr MJ, Deretic V
J Bacteriol 1995 Jun;177(11):3259-68
PubMed ID: 7768826
|
Control of AlgU, a member of the sigma E-like family of stress sigma factors, by the negative regulators MucA and MucB and Pseudomonas aeruginosa conversion to mucoidy in cystic fibrosis.
Schurr MJ, Yu H, Martinez-Salazar JM, Boucher JC, Deretic V
J Bacteriol 1996 Aug;178(16):4997-5004
PubMed ID: 8759866
|
A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and algT/U activity results in the loss of alginate production.
Sautter R, Ramos D, Schneper L, Ciofu O, Wassermann T, Koh CL, Heydorn A, Hentzer M, Høiby N, Kharazmi A, Molin S, Devries CA, Ohman DE, Mathee K
Gene 2012 May 1;498(2):242-53
PubMed ID: 22088575
|