Pseudomonas aeruginosa PAO1, PA0778 (icp)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0778
Name
icp
Replicon chromosome
Genomic location 845278 - 845682 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249469.1
GI 15595975
Affymetrix PA0778_at
DNASU PaCD00006356
Entrez 879252
GenBank AAG04167.1
INSDC AAG04167.1
NCBI Locus Tag PA0778
protein_id(GenBank) gb|AAG04167.1|AE004512_10|gnl|PseudoCAP|PA0778
TIGR NTL03PA00779
UniParc UPI00000C5148
UniProtKB Acc Q9I5G0
UniProtKB ID Q9I5G0_PSEAE
UniRef100 UniRef100_Q9I5G0
UniRef50 UniRef50_Q9I5G0
UniRef90 UniRef90_Q9I5G0

Product

Feature Type CDS
Coding Frame 1
Product Name
inhibitor of cysteine peptidase
Product Name Confidence: Class 1
Synonyms chagasin-like protein
Evidence for Translation
Charge (pH 7) -4.10
Kyte-Doolittle Hydrophobicity Value -0.259
Molecular Weight (kDa) 14.6
Isoelectric Point (pI) 4.58

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2WGN HYDROLASE INHIBITOR 04/21/09 Pseudomonas aeruginosa ICP PSEUDOMONAS AERUGINOSA NOT SOLUTION NMR 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 39 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000752 (540 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0778
Search term: icp

References

Functional conservation of a natural cysteine peptidase inhibitor in protozoan and bacterial pathogens.
Sanderson SJ, Westrop GD, Scharfstein J, Mottram JC, Coombs GH
FEBS Lett. 2003 May;542(1-3):12-6
PubMed ID: 12729889
Sequence conservation in the chagasin family suggests a common trend in cysteine proteinase binding by unrelated protein inhibitors.
Rigden DJ, Mosolov VV, Galperin MY
Protein Sci. 2002 Aug;11(8):1971-7
PubMed ID: 12142451
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res. 2005 Feb;15(2):321-9
PubMed ID: 15687295