Pseudomonas aeruginosa PAO1, PA0837 (slyD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0837
Name
slyD
Replicon chromosome
Genomic location 913086 - 913571 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_249528.1
GI 15596034
Affymetrix PA0837_slyD_at
DNASU PaCD00006383
Entrez 880885
GenBank AAG04226.1
INSDC AAG04226.1
NCBI Locus Tag PA0837
protein_id(GenBank) gb|AAG04226.1|AE004518_7|gnl|PseudoCAP|PA0837
TIGR NTL03PA00838
UniParc UPI00000C5180
UniProtKB Acc Q9I5A3
UniProtKB ID Q9I5A3_PSEAE
UniRef100 UniRef100_W0YP22
UniRef50 UniRef50_A6VAE2
UniRef90 UniRef90_A6VAE2

Product

Feature Type CDS
Coding Frame 1
Product Name
peptidyl-prolyl cis-trans isomerase SlyD
Product Name Confidence: Class 2
Synonyms rotamase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by two-dimensional gel electrophoresis and mass spectral analysis(PMID:21863142).
Charge (pH 7) -17.84
Kyte-Doolittle Hydrophobicity Value -0.174
Molecular Weight (kDa) 17.0
Isoelectric Point (pI) 4.23

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 353 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000805 (551 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0837
Search term: slyD

References

An Escherichia coli protein consisting of a domain homologous to FK506-binding proteins (FKBP) and a new metal binding motif.
Wülfing C, Lombardero J, Plückthun A
J. Biol. Chem. 1994 Jan;269(4):2895-901
PubMed ID: 8300624
The Escherichia coli SlyD is a metal ion-regulated peptidyl-prolyl cis/trans-isomerase.
Hottenrott S, Schumann T, Plückthun A, Fischer G, Rahfeld JU
J. Biol. Chem. 1997 Jun;272(25):15697-701
PubMed ID: 9188461
Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient.
Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB
Front Microbiol 2011 ;2
PubMed ID: 21863142