Pseudomonas aeruginosa PAO1, PA0847

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0847
Name
Replicon chromosome
Genomic location 925007 - 927214 (- strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs
CommentOverexpression of PA0847 increaes pellicle formation.

Cross-References

RefSeq NP_249538.1
GI 15596044
Affymetrix PA0847_at
Entrez 882143
GenBank AAG04236.1
INSDC AAG04236.1
NCBI Locus Tag PA0847
protein_id(GenBank) gb|AAG04236.1|AE004519_7|gnl|PseudoCAP|PA0847
TIGR NTL03PA00848
UniParc UPI00000C5186
UniProtKB Acc Q9I594
UniProtKB ID Q9I594_PSEAE
UniRef100 UniRef100_Q9I594
UniRef50 UniRef50_M4X1B7
UniRef90 UniRef90_Q9I594

Product

Feature Type CDS
Coding Frame 1
Product Name
diguanylate cyclase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -10.25
Kyte-Doolittle Hydrophobicity Value -0.282
Molecular Weight (kDa) 82.6
Isoelectric Point (pI) 5.90

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 490 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000814 (342 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0847

References

Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence.
Kulasakara H, Lee V, Brencic A, Liberati N, Urbach J, Miyata S, Lee DG, Neely AN, Hyodo M, Hayakawa Y, Ausubel FM, Lory S
Proc. Natl. Acad. Sci. U.S.A. 2006 Feb;103(8):2839-44
PubMed ID: 16477007
Characterization and analysis of a novel diguanylate cyclase PA0847 from <i>Pseudomonas aeruginosa</i> PAO1.
Zhang Y, Guo J, Zhang N, Yuan W, Lin Z, Huang W
Infect Drug Resist 2019;12:655-665
PubMed ID: 31114257