Pseudomonas aeruginosa PAO1, PA0923 (dinB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0923
Name
dinB
Synonym: dinP
Synonym: dinB
Replicon chromosome
Genomic location 1007950 - 1008999 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249614.1
GI 15596120
Affymetrix PA0923_dinP_at
Entrez 881987
GenBank AAG04312.1
INSDC AAG04312.1
NCBI Locus Tag PA0923
protein_id(GenBank) gb|AAG04312.1|AE004526_7|gnl|PseudoCAP|PA0923
TIGR NTL03PA00924
UniParc UPI000012979E
UniProtKB Acc Q9I534
UniProtKB ID DPO4_PSEAE
UniRef100 UniRef100_Q02I83
UniRef50 UniRef50_Q88NK4
UniRef90 UniRef90_Q02I83

Product

Feature Type CDS
Coding Frame 1
Product Name
DNA Polymerase IV, DinB
Product Name Confidence: Class 1
Synonyms DNA damage inducible protein P
DNA Polymerase IV, DinB
DinB
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 3.72
Kyte-Doolittle Hydrophobicity Value -0.182
Molecular Weight (kDa) 38.9
Isoelectric Point (pI) 8.07

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 519 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000889 (553 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0923
Search term: dinB

Human Homologs

Ensembl 97, assembly GRCh38.p12
REV1 DNA directed polymerase [Source:HGNC Symbol;Acc:HGNC:14060]
E-value: 4.4e-35
Percent Identity: 29.8

References

Role of Pseudomonas aeruginosa dinB-encoded DNA polymerase IV in mutagenesis.
Sanders LH, Rockel A, Lu H, Wozniak DJ, Sutton MD
J Bacteriol 2006 Dec;188(24):8573-85
PubMed ID: 17041045
dinP, a new gene in Escherichia coli, whose product shows similarities to UmuC and its homologues.
Ohmori H, Hatada E, Qiao Y, Tsuji M, Fukuda R
Mutat. Res. 1995 Jun;347(1):1-7
PubMed ID: 7596361
Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA.
Kim SR, Maenhaut-Michel G, Yamada M, Yamamoto Y, Matsui K, Sofuni T, Nohmi T, Ohmori H
Proc. Natl. Acad. Sci. U.S.A. 1997 Dec;94(25):13792-7
PubMed ID: 9391106