Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA0936
|
Name |
lpxO2
|
Replicon | chromosome |
Genomic location | 1026274 - 1027212 (- strand) |
Transposon Mutants | 3 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
Comment | LpxO2 appears to be responsible for most of lipid A hydroxylation in Pseudomonas aeruginosa PAO1 (PMID:31835493). |
RefSeq | NP_249627.1 |
GI | 15596133 |
Affymetrix | PA0936_at |
DNASU | PaCD00006428 |
Entrez | 878312 |
GenBank | AAG04325.1 |
INSDC | AAG04325.1 |
NCBI Locus Tag | PA0936 |
protein_id(GenBank) | gb|AAG04325.1|AE004528_3|gnl|PseudoCAP|PA0936 |
TIGR | NTL03PA00937 |
UniParc | UPI00000C51C8 |
UniProtKB Acc | Q9I522 |
UniProtKB ID | Q9I522_PSEAE |
UniRef100 | UniRef100_Q9I522 |
UniRef50 | UniRef50_Q4KGI6 |
UniRef90 | UniRef90_Q9I522 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
lipopolysaccharide biosynthetic protein LpxO2
|
Synonyms |
lipopolysaccharide biosynthetic protein Lpx02 |
Evidence for Translation |
Detected using LC-MS/MS (35.76 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | 16.34 |
Kyte-Doolittle Hydrophobicity Value | -0.138 |
Molecular Weight (kDa) | 35.8 |
Isoelectric Point (pI) | 10.30 |
Individual Mappings | |
Additional evidence for subcellular localization |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 84 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000902 (489 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA0936
Search term: lpxO2
Search term: lipopolysaccharide biosynthetic protein LpxO2
|
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
|
Oxygen requirement for the biosynthesis of the S-2-hydroxymyristate moiety in Salmonella typhimurium lipid A. Function of LpxO, A new Fe2+/alpha-ketoglutarate-dependent dioxygenase homologue.
Gibbons HS, Lin S, Cotter RJ, Raetz CR
J Biol Chem 2000 Oct 20;275(42):32940-9
PubMed ID: 10903325
|
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344
|
Genetic Basis and Physiological Effects of Lipid A Hydroxylation in Pseudomonas aeruginosa PAO1.
Lo Sciuto A, Cervoni M, Stefanelli R, Spinnato MC, Di Giamberardino A, Mancone C, Imperi F
Pathogens 2019 Dec 10;8(4)
PubMed ID: 31835493
|