Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA1003
|
Name |
mvfR
Synonym: pqsR |
Replicon | chromosome |
Genomic location | 1086097 - 1087095 (- strand) |
Transposon Mutants | 3 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
Comment | Quinolone signal response |
RefSeq | NP_249694.1 |
GI | 15596200 |
Affymetrix | PA1003_at |
DNASU | PaCD00006463 |
Entrez | 879994 |
GenBank | AAG04392.1 |
INSDC | AAG04392.1 |
NCBI Locus Tag | PA1003 |
protein_id(GenBank) | gb|AAG04392.1|AE004533_3|gnl|PseudoCAP|PA1003 |
TIGR | NTL03PA01004 |
UniParc | UPI00000C51FB |
UniProtKB Acc | Q9I4X0 |
UniProtKB ID | Q9I4X0_PSEAE |
UniRef100 | UniRef100_W0YN21 |
UniRef50 | UniRef50_Q02IG8 |
UniRef90 | UniRef90_Q02IG8 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
Transcriptional regulator MvfR
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | 1.77 |
Kyte-Doolittle Hydrophobicity Value | -0.138 |
Molecular Weight (kDa) | 37.2 |
Isoelectric Point (pI) | 7.56 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
7P4U | GENE REGULATION | 07/13/21 | Crystal structure of PqsR (MvfR) ligand-binding domain in complex with 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 2.74 | X-RAY DIFFRACTION | 100.0 |
4JVC | TRANSCRIPTION REGULATOR | 03/25/13 | Crystal structure of PqsR co-inducer binding domain | Pseudomonas aeruginosa | 2.5 | X-RAY DIFFRACTION | 100.0 |
4JVI | TRANSCRIPTION REGULATOR/INHIBITOR | 03/25/13 | Crystal structure of PqsR co-inducer binding domain of Pseudomonas aeruginosa with inhibitor 3NH2-7Cl-C9QZN | Pseudomonas aeruginosa | 2.9 | X-RAY DIFFRACTION | 100.0 |
6Q7U | DNA BINDING PROTEIN | 12/13/18 | Crystal structure of PqsR (MvfR) ligand-binding domain in complex with HHQ | Pseudomonas aeruginosa PAO1 | 3.14 | X-RAY DIFFRACTION | 100.0 |
6TPR | DNA BINDING PROTEIN | 12/14/19 | PqsR (MvfR) bound to inhibitory compound 40 | Pseudomonas aeruginosa UCBPP-PA14 | 3.2 | X-RAY DIFFRACTION | 100.0 |
6YZ3 | DNA BINDING PROTEIN | 05/06/20 | PqsR (MvfR) in complex with antagonist 19 | Pseudomonas aeruginosa | 3 | X-RAY DIFFRACTION | 100.0 |
7O2U | DNA BINDING PROTEIN | 03/31/21 | PqsR (MvfR) in complex with antagonist 40 | Pseudomonas aeruginosa | 3 | X-RAY DIFFRACTION | 100.0 |
6YIZ | DNA BINDING PROTEIN | 04/01/20 | Crystal structure of PqsR (MvfR) ligand-binding domain in complex with triazolo-pyridine inverse agonist A | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 2.163 | X-RAY DIFFRACTION | 100.0 |
6Z17 | DNA BINDING PROTEIN | 05/12/20 | PqsR (MvfR) in complex with antagonist 6 | Pseudomonas aeruginosa (strain UCBPP-PA14) | 3.15 | X-RAY DIFFRACTION | 100.0 |
7QA0 | GENE REGULATION | 11/15/21 | Crystal structure of PqsR (MvfR) ligand-binding domain in complex with compound 1456 | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 2.67 | X-RAY DIFFRACTION | 100.0 |
6Z5K | DNA BINDING PROTEIN | 05/26/20 | PqsR (MvfR) in complex with antagonist 18 | Pseudomonas aeruginosa (strain UCBPP-PA14) | 3.201 | X-RAY DIFFRACTION | 100.0 |
6Q7V | DNA BINDING PROTEIN | 12/13/18 | Crystal structure of PqsR (MvfR) ligand-binding domain in complex with compound 11 | Pseudomonas aeruginosa PAO1 | 2.56 | X-RAY DIFFRACTION | 100.0 |
7O2T | DNA BINDING PROTEIN | 03/31/21 | PqsR (MvfR) in complex with antagonist 61 | Pseudomonas aeruginosa | 2.65 | X-RAY DIFFRACTION | 100.0 |
6Z07 | DNA BINDING PROTEIN | 05/07/20 | PqsR (MvfR) in complex with antagonist 12 | Pseudomonas aeruginosa (strain UCBPP-PA14) | 2.95 | X-RAY DIFFRACTION | 100.0 |
6B8A | TRANSCRIPTION | 10/05/17 | Crystal structure of MvfR ligand binding domain in complex with M64 | Pseudomonas aeruginosa | 2.65 | X-RAY DIFFRACTION | 100.0 |
7NBW | DNA BINDING PROTEIN | 01/28/21 | Crystal structure of PqsR (MvfR) ligand-binding domain in complex with a pyridin agonist | Pseudomonas aeruginosa PAO1 | 2.28 | X-RAY DIFFRACTION | 100.0 |
7QAV | GENE REGULATION | 11/17/21 | Crystal structure of PqsR (MvfR) ligand-binding domain in complex with compound N-((2-(4-cyclopropylphenyl)thiazol-5-yl)methyl)-2-(trifluoromethyl)pyridin-4-amine | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 2.65 | X-RAY DIFFRACTION | 99.7 |
6Q7W | DNA BINDING PROTEIN | 12/13/18 | Crystal structure of PqsR (MvfR) ligand-binding domain in complex with compound 20 | Pseudomonas aeruginosa PAO1 | 2.82 | X-RAY DIFFRACTION | 100.0 |
4JVD | TRANSCRIPTION REGULATOR | 03/25/13 | Crystal structure of PqsR coinducer binding domain of Pseudomonas aeruginosa with ligand NHQ | Pseudomonas aeruginosa | 2.95 | X-RAY DIFFRACTION | 100.0 |
7QA3 | GENE REGULATION | 11/15/21 | Crystal structure of PqsR (MvfR) ligand-binding domain in complex with compound N-((2-(4-phenoxyphenyl)thiazol-5-yl)methyl)-2-(trifluoromethyl)pyridin-4-amine | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 2.67 | X-RAY DIFFRACTION | 100.0 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 139 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000966 (291 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA1003
Search term: mvfR
Search term: Transcriptional regulator MvfR
|
A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism.
Cao H, Krishnan G, Goumnerov B, Tsongalis J, Tompkins R, Rahme LG
Proc Natl Acad Sci U S A 2001 Dec 4;98(25):14613-8
PubMed ID: 11724939
|
Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication.
Déziel E, Lépine F, Milot S, He J, Mindrinos MN, Tompkins RG, Rahme LG
Proc Natl Acad Sci U S A 2004 Feb 3;101(5):1339-44
PubMed ID: 14739337
|
The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl-L-homoserine lactones.
Déziel E, Gopalan S, Tampakaki AP, Lépine F, Padfield KE, Saucier M, Xiao G, Rahme LG
Mol Microbiol 2005 Feb;55(4):998-1014
PubMed ID: 15686549
|