Pseudomonas aeruginosa PAO1, PA1013 (purC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA1013
Name
purC
Replicon chromosome
Genomic location 1096063 - 1096773 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249704.1
GI 15596210
Affymetrix PA1013_purC_at
DNASU PaCD00006466
Entrez 881642
GenBank AAG04402.1
INSDC AAG04402.1
NCBI Locus Tag PA1013
protein_id(GenBank) gb|AAG04402.1|AE004533_13|gnl|PseudoCAP|PA1013
TIGR NTL03PA01014
UniParc UPI0000132AA4
UniProtKB Acc Q9I4W0
UniProtKB ID PUR7_PSEAE
UniRef100 UniRef100_B7UXT0
UniRef50 UniRef50_Q4KGP5
UniRef90 UniRef90_B7UXT0

Product

Feature Type CDS
Coding Frame 1
Product Name
phosphoribosylaminoimidazole-succinocarboxamide synthase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -4.60
Kyte-Doolittle Hydrophobicity Value -0.306
Molecular Weight (kDa) 26.8
Isoelectric Point (pI) 5.08

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 542 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000976 (510 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1013
Search term: purC

References

Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway.
Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM
Biochemistry 1992 Jun 2;31(21):5022-32
PubMed ID: 1534690
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994