Pseudomonas aeruginosa PAO1, PA1125

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA1125
Name
Synonym: cobB
Replicon chromosome
Genomic location 1218181 - 1218933 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_249816.1
GI 15596322
Affymetrix PA1125_at
DNASU PaCD00006518
Entrez 879981
GenBank AAG04514.1
INSDC AAG04514.1
NCBI Locus Tag PA1125
protein_id(GenBank) gb|AAG04514.1|AE004542_10|gnl|PseudoCAP|PA1125
TIGR NTL03PA01126
UniParc UPI00000C525F
UniProtKB Acc Q9I4L0
UniProtKB ID NPD1_PSEAE
UniRef100 UniRef100_Q9I4L0
UniRef50 UniRef50_A0R2N3
UniRef90 UniRef90_Q9I4L0

Product

Feature Type CDS
Coding Frame 1
Product Name
probable cobalamin biosynthetic protein
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) 1.95
Kyte-Doolittle Hydrophobicity Value 0.004
Molecular Weight (kDa) 26.7
Isoelectric Point (pI) 7.53

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 447 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001085 (459 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1125

Human Homologs

Ensembl 97, assembly GRCh38.p12
sirtuin 5 [Source:HGNC Symbol;Acc:HGNC:14933]
E-value: 8.2e-44
Percent Identity: 41.5

References

An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae.
Philipp WJ, Poulet S, Eiglmeier K, Pascopella L, Balasubramanian V, Heym B, Bergh S, Bloom BR, Jacobs WR, Cole ST
Proc. Natl. Acad. Sci. U.S.A. 1996 Apr;93(7):3132-7
PubMed ID: 8610181
CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis in Salmonella typhimurium LT2.
Tsang AW, Escalante-Semerena JC
J. Biol. Chem. 1998 Nov;273(48):31788-94
PubMed ID: 9822644