Pseudomonas aeruginosa PAO1, PA1130 (rhlC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1130
Name
rhlC
Replicon chromosome
Genomic location 1222095 - 1223072 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_249821.1
GI 15596327
Affymetrix PA1130_at
Entrez 877665
GenBank AAG04519.1
INSDC AAG04519.1
NCBI Locus Tag PA1130
protein_id(GenBank) gb|AAG04519.1|AE004543_3|gnl|PseudoCAP|PA1130
TIGR NTL03PA01131
UniParc UPI00000C5264
UniProtKB Acc Q9I4K5
UniProtKB ID Q9I4K5_PSEAE
UniRef100 UniRef100_Q9I4K5
UniRef50 UniRef50_Q9I4K5
UniRef90 UniRef90_Q9I4K5

Product

Feature Type CDS
Coding Frame 1
Product Name
rhamnosyltransferase 2
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 16.07
Kyte-Doolittle Hydrophobicity Value -0.153
Molecular Weight (kDa) 35.9
Isoelectric Point (pI) 10.98

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0089
Category Rhamnolipid biosynthesis
Evidence
Host Organism
Notes
Reference

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 88 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001090 (296 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1130
Search term: rhlC

Human Homologs

References

Cloning and functional characterization of the Pseudomonas aeruginosa rhlC gene that encodes rhamnosyltransferase 2, an enzyme responsible for di-rhamnolipid biosynthesis.
Rahim R, Ochsner UA, Olvera C, Graninger M, Messner P, Lam JS, Soberón-Chávez G
Mol Microbiol 2001 May;40(3):708-18
PubMed ID: 11359576
Function of the rfb gene cluster and the rfe gene in the synthesis of O antigen by Shigella dysenteriae 1.
Klena JD, Schnaitman CA
Mol Microbiol 1993 Jul;9(2):393-402
PubMed ID: 7692219