Pseudomonas aeruginosa PAO1, PA1163 (ndvB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA1163
Name
ndvB
Synonym: ndvB
Replicon chromosome
Genomic location 1260557 - 1263166 (- strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 7 transposon mutants in orthologs
Commentrequired for the synthesis of periplasmic glucans, and involved in biofilm-specific resistance to a subset of antibiotics

Cross-References

RefSeq NP_249854.1
GI 15596360
Affymetrix PA1163_at
Entrez 877810
GenBank AAG04552.1
INSDC AAG04552.1
NCBI Locus Tag PA1163
protein_id(GenBank) gb|AAG04552.1|AE004546_7|gnl|PseudoCAP|PA1163
TIGR NTL03PA01164
UniParc UPI00000C5281
UniProtKB Acc Q9I4H4
UniProtKB ID Q9I4H4_PSEAE
UniRef100 UniRef100_Q9I4H4
UniRef50 UniRef50_Q9I4H4
UniRef90 UniRef90_Q9I4H4

Product

Feature Type CDS
Coding Frame 1
Product Name
NdvB
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 13.66
Kyte-Doolittle Hydrophobicity Value 0.162
Molecular Weight (kDa) 97.0
Isoelectric Point (pI) 9.14

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 379 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000682 (2168 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1163
Search term: ndvB
Search term: NdvB

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance.
Mah TF, Pitts B, Pellock B, Walker GC, Stewart PS, O'Toole GA
Nature 2003 Nov;426(6964):306-10
PubMed ID: 14628055
High-level antibiotic resistance in Pseudomonas aeruginosa biofilm: the ndvB gene is involved in the production of highly glycerol-phosphorylated beta-(1->3)-glucans, which bind aminoglycosides.
Sadovskaya I, Vinogradov E, Li J, Hachani A, Kowalska K, Filloux A
Glycobiology 2010 Jul;20(7):895-904
PubMed ID: 20348539