Pseudomonas aeruginosa PAO1, PA1169

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA1169
Name
Replicon chromosome
Genomic location 1267680 - 1269737 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249860.1
GI 15596366
Affymetrix PA1169_at
Entrez 879547
GenBank AAG04558.1
INSDC AAG04558.1
NCBI Locus Tag PA1169
protein_id(GenBank) gb|AAG04558.1|AE004547_4|gnl|PseudoCAP|PA1169
TIGR NTL03PA01170
UniParc UPI00000C5287
UniProtKB Acc Q9I4G8
UniProtKB ID LOXA_PSEAE
UniRef100 UniRef100_Q9I4G8
UniRef50 UniRef50_Q8RNT4
UniRef90 UniRef90_Q8RNT4

Product

Feature Type CDS
Coding Frame 1
Product Name
probable lipoxygenase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) -1.42
Kyte-Doolittle Hydrophobicity Value 0.023
Molecular Weight (kDa) 74.8
Isoelectric Point (pI) 6.75

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5IR5 OXIDOREDUCTASE 03/12/16 Crystal structure of wild-type bacterial lipoxygenase from Pseudomonas aeruginosa PA-LOX with space group P21212 at 1.9 A resolution PSEUDOMONAS AERUGINOSA 1.9 X-RAY DIFFRACTION 98.5
4RPE OXIDOREDUCTASE 10/30/14 Crystal Structure of Variant G186E from Pseudomonas Aeruginosa Lipoxygenase 2 at 1.60A (C2) PSEUDOMONAS AERUGINOSA 1.6 X-RAY DIFFRACTION 98.4
5IR4 OXIDOREDUCTASE 03/12/16 Crystal structure of wild-type bacterial lipoxygenase from Pseudomonas aeruginosa PA-LOX with space group C2221 at 1.48 A resolution PSEUDOMONAS AERUGINOSA 1.48 X-RAY DIFFRACTION 98.5
5LC8 OXIDOREDUCTASE 06/20/16 Crystal Structure of specific mutant from Pseudomonas aeruginosa Lipoxygenase at 1.8A resolution PSEUDOMONAS AERUGINOSA 1.8 X-RAY DIFFRACTION 98.8
4G32 OXIDOREDUCTASE 07/13/12 Crystal Structure of a Phospholipid-Lipoxygenase Complex from Pseudomonas aeruginosa at 1.75A (P21212) PSEUDOMONAS AERUGINOSA 1.75 X-RAY DIFFRACTION 98.5
4G33 OXIDOREDUCTASE 07/13/12 Crystal Structure of a Phospholipid-Lipoxygenase Complex from Pseudomonas aeruginosa at 2.0 A (C2221) PSEUDOMONAS AERUGINOSA 2.03 X-RAY DIFFRACTION 98.5

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 20 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001127 (301 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1169

Human Homologs

Ensembl 97, assembly GRCh38.p12
arachidonate lipoxygenase 3 [Source:HGNC Symbol;Acc:HGNC:13743]
E-value: 1.2e-52
Percent Identity: 30.6

Human Homologs

Ensembl 97, assembly GRCh38.p12
arachidonate lipoxygenase 3 [Source:HGNC Symbol;Acc:HGNC:13743]
E-value: 1.2e-52
Percent Identity: 30.6

Human Homologs

Ensembl 97, assembly GRCh38.p12
arachidonate lipoxygenase 3 [Source:HGNC Symbol;Acc:HGNC:13743]
E-value: 1.2e-52
Percent Identity: 30.6

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Molecular cloning and functional expression of a phorbol ester-inducible 8S-lipoxygenase from mouse skin.
Jisaka M, Kim RB, Boeglin WE, Nanney LB, Brash AR
J. Biol. Chem. 1997 Sep;272(39):24410-6
PubMed ID: 9305900