Pseudomonas aeruginosa PAO1, PA1183 (dctA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA1183
Name
dctA
Replicon chromosome
Genomic location 1284513 - 1285823 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249874.1
GI 15596380
Affymetrix PA1183_dctA_at
Entrez 880848
GenBank AAG04572.1
INSDC AAG04572.1
NCBI Locus Tag PA1183
protein_id(GenBank) gb|AAG04572.1|AE004548_6|gnl|PseudoCAP|PA1183
TIGR NTL03PA01184
UniParc UPI0000129926
UniProtKB Acc Q9I4F5
UniProtKB ID DCTA2_PSEAE
UniRef100 UniRef100_Q02J03
UniRef50 UniRef50_P96603
UniRef90 UniRef90_Q02J03

Product

Feature Type CDS
Coding Frame 1
Product Name
C4-dicarboxylate transport protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 3.52
Kyte-Doolittle Hydrophobicity Value 0.778
Molecular Weight (kDa) 46.0
Isoelectric Point (pI) 8.20

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 432 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001141 (527 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1183
Search term: dctA

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Utilization of orotate as a pyrimidine source by Salmonella typhimurium and Escherichia coli requires the dicarboxylate transport protein encoded by dctA.
Baker KE, Ditullio KP, Neuhard J, Kelln RA
J. Bacteriol. 1996 Dec;178(24):7099-105
PubMed ID: 8955389
Identification of C(4)-dicarboxylate transport systems in Pseudomonas aeruginosa PAO1.
Valentini M, Storelli N, Lapouge K
J. Bacteriol. 2011 Sep;193(17):4307-16
PubMed ID: 21725012