Pseudomonas aeruginosa PAO1, PA1277 (cobQ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA1277
Name
cobQ
Synonym: cbiP
Replicon chromosome
Genomic location 1388242 - 1389714 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_249968.1
GI 15596474
Affymetrix PA1277_cobQ_at
Entrez 881421
GenBank AAG04666.1
INSDC AAG04666.1
NCBI Locus Tag PA1277
protein_id(GenBank) gb|AAG04666.1|AE004557_7|gnl|PseudoCAP|PA1277
TIGR NTL03PA01278
UniParc UPI00000C52E5
UniProtKB Acc Q9I467
UniProtKB ID COBQ_PSEAE
UniRef100 UniRef100_Q9I467
UniRef50 UniRef50_P29932
UniRef90 UniRef90_Q9I467

Product

Feature Type CDS
Coding Frame 1
Product Name
cobyric acid synthase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -4.79
Kyte-Doolittle Hydrophobicity Value 0.012
Molecular Weight (kDa) 52.4
Isoelectric Point (pI) 6.40

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 396 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001224 (547 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1277
Search term: cobQ

References

Biosynthesis of vitamin B12: stepwise amidation of carboxyl groups b, d, e, and g of cobyrinic acid a,c-diamide is catalyzed by one enzyme in Pseudomonas denitrificans.
Blanche F, Couder M, Debussche L, Thibaut D, Cameron B, Crouzet J
J Bacteriol 1991 Oct;173(19):6046-51
PubMed ID: 1917839
Nucleotide sequence and genetic analysis of a 13.1-kilobase-pair Pseudomonas denitrificans DNA fragment containing five cob genes and identification of structural genes encoding Cob(I)alamin adenosyltransferase, cobyric acid synthase, and bifunctional cobinamide kinase-cobinamide phosphate guanylyltransferase.
Crouzet J, Levy-Schil S, Cameron B, Cauchois L, Rigault S, Rouyez MC, Blanche F, Debussche L, Thibaut D
J Bacteriol 1991 Oct;173(19):6074-87
PubMed ID: 1655697