Pseudomonas aeruginosa PAO1, PA1338 (ggt)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA1338
Name
ggt
Replicon chromosome
Genomic location 1451719 - 1453392 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_250029.1
GI 15596535
Affymetrix PA1338_ggt_at
Entrez 882262
GenBank AAG04727.1
INSDC AAG04727.1
NCBI Locus Tag PA1338
protein_id(GenBank) gb|AAG04727.1|AE004563_4|gnl|PseudoCAP|PA1338
TIGR NTL03PA01339
UniParc UPI00000C5321
UniProtKB Acc Q9I406
UniProtKB ID GGT_PSEAE
UniRef100 UniRef100_Q9I406
UniRef50 UniRef50_Q9I406
UniRef90 UniRef90_Q9I406

Product

Feature Type CDS
Coding Frame 1
Product Name
gamma-glutamyltranspeptidase precursor
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -4.58
Kyte-Doolittle Hydrophobicity Value -0.138
Molecular Weight (kDa) 59.9
Isoelectric Point (pI) 6.21

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 2
Periplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 391 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000352 (873 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1338
Search term: ggt

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res. 2005 Feb;15(2):321-9
PubMed ID: 15687295
Molecular cloning of Escherichia coli K-12 ggt and rapid isolation of gamma-glutamyltranspeptidase.
Suzuki H, Kumagai H, Echigo T, Tochikura T
Biochem. Biophys. Res. Commun. 1988 Jan;150(1):33-8
PubMed ID: 2892489
DNA sequence of the Escherichia coli K-12 gamma-glutamyltranspeptidase gene, ggt.
Suzuki H, Kumagai H, Echigo T, Tochikura T
J. Bacteriol. 1989 Sep;171(9):5169-72
PubMed ID: 2570061
Escherichia coli gamma-glutamyltranspeptidase mutants deficient in processing to subunits.
Hashimoto W, Suzuki H, Nohara S, Kumagai H
Biochem. Biophys. Res. Commun. 1992 Nov;189(1):173-8
PubMed ID: 1360205
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994